Marvel Studios faces a rare opportunity with Avengers: Doomsday to unite properties that have operated largely in isolation. The Russo Brothers' return to direct the film signals ambition at the studio level. With the multiverse now firmly established as MCU canon through Doctor Strange in the Multiverse of Madness, Spider-Man: No Way Home, and Deadpool & Wolverine, the infrastructure exists for long-awaited team-ups.
The X-Men represent the most obvious play. Fox's mutant universe now belongs to Marvel Studios, and audiences have waited decades to see the X-Men interact with the Avengers on screen. Kevin Feige has X-Force and other mutant-centric projects in development, making their integration into Doomsday plausible. Similarly, the Fantastic Four's MCU debut creates another crossover avenue. Jon Watts' upcoming Fantastic Four film positions the family as major players in the MCU's Phase 6 architecture.
The Blade franchise, with Mahershala Ali already cast, could slot into Doomsday's narrative, particularly if the Avengers face supernatural threats. The Thunderbolts/Dark Avengers roster offers a wildcard option, with characters like Yelena Belova and Bucky Barnes positioned as potential allies or antagonists depending on the plot.
Guardians of the Galaxy's post-Endgame evolution means Peter Quill's team could play a role. Doctor Strange's ongoing mystical storylines might necessitate that magic-focused Avengers involvement. Black Widow's spy network still has untapped potential through characters like Taskmaster.
The multiverse angle opens doors to Tobey Maguire and Andrew Garfield's Spider-Men, though their involvement hinges on No Way Home's narrative threads. Josh Brolin