Spider-Man has identified David Colton, also known as Miracleman, as the one Marvel superhero he absolutely cannot stand. The two clash after Colton destroys military weaponry at Stark Tower as part of his global crusade. Spider-Man accuses Colton of responsibility for Thunderbolt Ross "blowing up in Russia, killing thousands" and of trashing half of Europe while fighting the Red Hulk. Disgusted by how Colton's actions have made the world fear superheroes, Spider-Man physically expresses his grievances, forcing Mayor Luke Cage to intervene personally.

Colton joins a newly formed Avengers team alongside Spider-Man, Captain Marvel, Wolverine, Daredevil, Luke Cage, and Miracleman following the events of Avengers: Armageddon. The storyline stems from public distrust of superheroes reaching levels not seen since the Civil War event. Colton threw most of the world's nuclear weapons into the sun, an act Spider-Man views as largely responsible for the current public fear of enhanced individuals.

Despite their friction, Spider-Man must work with Colton to face new threats. Avengers #1 establishes the team battling Mephisto, who was usurped as Hell's ruler by Doctor Doom and now seeks to reverse voided contracts. S.H.I.E.L.D. has also begun targeting all superheroes after the United Nations agreed to fund the agency in exchange for enforcing a superpowers ban, approved by all member states except the United States. Nick Fury Sr. and resurrected Bucky Barnes team up to counter these efforts in the Immortal Soldiers one-shot.